Inhibiting Type VI Secretion System Activity with a Biomimetic Peptide Designed To Target the Baseplate Wedge Complex

ABSTRACT Human health is threatened by bacterial infections that are increasingly resistant to multiple drugs.A recently emerged strategy consists of disarming pathogenic bacteria by targeting and blocking their virulence factors.The type VI secretion system (T6SS) is a widespread secretion nanomachine encoded and employed by pathogenic strains to

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Biophysical induction of vascular smooth muscle cell podosomes.

Vascular smooth muscle cell (VSMC) migration and matrix degradation occurs with intimal hyperplasia associated with atherosclerosis, vascular injury, and restenosis.One proposed mechanism Skin Conditions by which VSMCs degrade matrix is through the use of podosomes, transient actin-based structures that are thought to play a role in extracellular m

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CRISPR/Cas9 for hepatitis B virus infection treatment

Abstract Hepatitis B virus (HBV) infection remains a Transfer Aides global health challenge.Despite the availability of effective preventive vaccines, millions of people are at risk of cirrhosis and hepatocellular carcinoma.Current drug therapies inhibit viral replication, slow the progression of liver fibrosis and reduce infectivity, but they rare

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